This is the Misión San Francisco De Asis
(Mission Dolores). http://www.graphicmode.com/missiondolores/ where St Francis served, and is pretty much where San Francisco (Saint, Francis) all began. Okay, actually it's not - this is the cathedral church built onto the side of the original mission, over the bones of another cathedral church built slightly earlier which didn't survive the 1909 quake.